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Think of the endocannabinoids yin and yang, an imbalance of one causes an imbalance of the other in the opposite way. All things in nature are biphasic, meaning more is not better and having too much can cause adverse effects. Think of it similar to Goldilocks and The Three Bears, Papa Bear’s porridge was too hot and burned her tongue , Mama Bear’s porridge was too cold and tasted horrible, but Baby Bear’s porridge was just right and could be eaten perfectly. The same story goes for cannabinoids, too much of any cannabinoid will have adverse effects, too little and there won’t be any effect at all, you need just the right amount of cannabinoids for the job to get done. We will take THC for example, too little THC you won’t feel any psychoactivity, too much THC you will feel it’s adverse effects such as paranoia and anxiety, and what was once a stress reliever is now a stress inducer. You need just the right amount of THC to give enough of an effect to be able to treat the ailment at hand.

Our body’s natural form of THC is anandamide, their function is similar as well. They are both full CB1 agonists and are responsible for managing the central nervous system functions. Now think of the symptoms someone who consumes THC too frequently, they suffer from ailments such as (but not limited to) anxiety, psychosis, onset seizures, fear, distrust, panic. The same is said in those that have the overproduction of anandamide. Those that suffer from elevated levels have been found to suffer from symptoms to that of consuming too much THC, which makes sense given they have a similar molecular structure and exhibit the same properties and function.
Lack of production of endocannabinoids the will cause ailments such as Alzheimer's, migraines, IBS, and fibromyalgia. Endocannabinoids are responsible for homeostasis and because of their lack of production the body will become unbalanced and begin to cause adverse effects and an imbalance in brain chemistry. Symptoms will vary in each patient. In the case of migraines concussion like symptoms, such as sensitivity to sound and light will present itself. With fibromyalgia symptoms include (but are not limited to) widespread muscular and physical pain, mood swings, and tingling sensations. Alzheimer’s has been found to occur due to a lack of production of endocannabinoids in the brain thus causing the memory loss associated with the condition.

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